BRAINSCAPES

The aim of BRAINSCAPES is to map in detail the biological mechanisms underlying multiple brain disorders ('brainscaping').

Recent genetic discovery studies have provided unprecedented insight into the genes involved in brain disorders. The next step is to use this knowledge for gaining mechanistic disease insight. In BRAINSCAPES we will develop novel analytic and experimental tools to study the functional consequences of risk genes on the function of specific cells, their circuits and functional output. We aim to provide insight into the molecular and cellular basis of complex brain disorders that can be used to design novel treatments.

The next step in brain related research

We won’t stop until we know it all, by using 5 complementing strategies:

News

April 9, 2021 / our-news

Uncovering functionally distinct anatomical circuits within the PFC

De Kloet et al. show that mPFC output pathways targeting anatomically and functionally distinct striatal and thalamic subregions encode bi-directional command of cognitive control.
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April 1, 2021 / our-news

Seed grant for OCD-related DBS research

He will receive $800,000 over four years for exploring neural mechanisms of deep-brain stimulation in a mouse model for OCD.
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March 19, 2021 / our-news

Biological discovery heralds new medication

According to research by UMC Utrecht and Oxford University: instead of competing, signaling proteins both bind to cell's receptor.
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February 19, 2021 / our-news

Brainscapes PIs join AI in Computational Life-Science program to enhance drug discovery in the brain

The possibilities to access the molecular data of cells and tissues are increasing, but this also creates new challenges.
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February 5, 2021 / our-news

KHMW Young Talent Award for Lieke Michielsen

The Royal Holland Society of Sciences and Humanities (KHMW) has awarded Lieke Michielsen (Delft University of Technology) a Pfizer Prize for Life Sciences 2020.
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January 22, 2021 / our-news

Exploring prefrontal brain mechanisms underlying behavioral inhibition

Terra et al. investigate the role of specific cortical neuron types that send projections from dorsal mPFC-to-medial dorsal striatum in behavioral inhibition.
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