BRAINSCAPES

The aim of BRAINSCAPES is to map in detail the biological mechanisms underlying multiple brain disorders ('brainscaping').

Recent genetic discovery studies have provided unprecedented insight into the genes involved in brain disorders. The next step is to use this knowledge for gaining mechanistic disease insight. In BRAINSCAPES we will develop novel analytic and experimental tools to study the functional consequences of risk genes on the function of specific cells, their circuits and functional output. We aim to provide insight into the molecular and cellular basis of complex brain disorders that can be used to design novel treatments.

News

November 28, 2022

Optimizing study designs for iPSC-based disease modelling

In a study published in Molecular Psychiatry on Nov 24th, three Brainscapes teams across two work packages worked together to optimize statistical power for iPSC-based study designs. Their analyses demonstrate that published case-control iPSC studies are generally underpowered. 
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October 6, 2022

BRAINSCAPES consortium day 2022

On Friday, September 30, the BRAINSCAPES annual meeting was held in Leiden at the CORPUS congress center. Over 50 members participated in the event and well represented the 7 institutes that are involved in the project.
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July 20, 2022

Characterising social stress responsive ventral tegmental area neurons

Researchers from UMC Utrecht characterized neurons in the ventral tegmental area that respond to stress, paving the way for future research into the functional contribution of this population to stress-driven changes in reward processing.
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June 12, 2022 / our-news

A map of dopamine signals across the brain

Researchers from the Netherlands Institute for Neuroscience reveal new functional insights on the dopamine signals across the brain, and publish their findings in PNAS.
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February 8, 2022 / our-news

Brainscapes scientists identify a yet unknown neural mechanism of habit formation

Researchers from the Amsterdam UMC, and part of the Brainscapes consortium, now show findings that challenge the status quo in the field of behavioral neuroscience.
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October 20, 2021 / our-news

Brainscapes participates in major successful brain mapping initiative

Two co-leaders of the Brainscapes consortium have contributed to successfully map the different cell types of the motor cortex and other cortical areas in the brain.
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September 21, 2021 / our-news

New genetic causes for Alzheimer’s discovered

An international research team has conducted large-scale genetic research into the different backgrounds of the risk of Alzheimer's disease. The researchers discovered new genes and biological mechanisms that contribute to Alzheimer's disease.
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